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KMID : 1161520120160040269
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Animal Cells and Systems
2012 Volume.16 No. 4 p.269 ~ p.273
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Calcium and bioenergetics: from endoplasmic reticulum to mitochondria
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Lee Duk-Gyu
Michalak Marek
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Abstract
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Controlling metabolism throughout life is a necessity for living creatures, and perturbation of energy balance elicits disorders such as type-2 diabetes mellitus and cardiovascular disease. Ca2+ plays a key role in regulating energy generation. Ca2+ homeostasis of the endoplasmic reticulum (ER) lumen is maintained through the action of Ca2+ channels and the Ca2+ ATPase pump. Once released from the ER, Ca2+ is taken up by mitochondria where it facilitates energy metabolism. Mitochondrial Ca2+ serves as a key metabolic regulator and determinant of cell fate, necrosis, and/or apoptosis. Here, we focus on Ca2+ transport from the ER to mitochondria, and Ca2+-dependent regulation of mitochondrial energy metabolism.
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KEYWORD
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Ca2+ homeostasis, receptor, endoplasmic reticulum, mitochondria, energy metabolism
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